Comprehensive prostate cancer assay

The Fluivia comprehensive prostate cancer assay detects somatic mutations, copy number changes, rearrangements and germline variants in 66 prostate cancer genes. The test can be used with circulating tumor DNA, fresh frozen cancer tissue, or FFPE cancer tissue. The assay interrogates all genes that are recurrently altered at the DNA level in prostate cancer, including genes related to hormonal signaling, steroid synthesis, cell cycle regulation, DNA repair, PI3K and WNT signaling. The panel provides a detailed view of genomic alterations at the androgen receptor (AR) locus, covering all AR exons and introns 3 - 7 to enable detection of intragenic rearrangements. The panel also interrogates the structure of AR locus amplifications using a high resolution (30 kb) probe grid. The assay also estimates a genome-wide copy number profile at 300 kb resolution, enabling absolute copy number quantification and detection of genome duplication events.

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700 - 1500€ per sample, depending on order volume. Sample shipping and analysis of matched germline samples is free of charge.

Panel content

GeneAnalyzed regions
AKT1Coding regions
APCCoding regions
ARCoding regions + introns 3 - 7 + flanking regions
ARID1ACoding regions
ASXL1Coding regions
ATMCoding regions
ATRCoding regions
BRAFCoding regions
BRCA1Coding regions
BRCA2Coding regions
CCND1Coding regions
CDK12Coding regions
CDK4Coding regions
CDK6Coding regions
CDKN1BCoding regions
CDKN2ACoding regions
CHD1Coding regions
CHEK1Coding regions
CHEK2Coding regions
CTNNB1Coding regions
CYP11A1Coding regions
CYP17A1Coding regions
ERCC2Coding regions
FANCACoding regions
FANCCCoding regions
FANCD2Coding regions
FANCLCoding regions
FBXW7Coding regions
FOXA1Coding regions
FOXP1Coding regions
HSD3B1Coding regions
IDH1Coding regions
KDM6ACoding regions
KMT2CCoding regions
KMT2DCoding regions
KRASCoding regions
MDM2Coding regions
MDM4Coding regions
MED12Coding regions
METCoding regions
MLH1Coding regions
MSH2Coding regions
MSH6Coding regions
MYCCoding regions
NCOA2Coding regions
NKX3-1Coding regions
PALB2Coding regions
PIK3CACoding regions
PIK3CBCoding regions
PIK3R1Coding regions
PMS2Coding regions
POLECoding regions
PTENCoding regions
RAD51BCoding regions
RAD51CCoding regions
RAD51DCoding regions
RB1Coding regions
RNF43Coding regions
RYBPCoding regions
SMARCA1Coding regions
SPOPCoding regions
SRD5A2Coding regions
TERTPromoter region
TP53Coding regions
ZBTB16Coding regions
ZFHX3Coding regions
Whole genomeProbes tiled at 300 kb intervals for genome-wide copy number analysis


Our circulating tumor DNA analysis methodology has been validated in internationally leading studies comparing circulating tumor DNA profiles against time-matched metastatic tissue biopsies and diagnostic biopsies: