Comprehensive ovarian cancer assay

The Fluivia comprehensive ovarian cancer assay detects somatic mutations, copy number changes, rearrangements and germline variants in 61 ovarian cancer genes. The test can be used with circulating tumor DNA, fresh frozen cancer tissue, or FFPE cancer tissue. The assay interrogates all genes that are recurrently altered at the DNA level in ovarian cancer, including genes related to cell cycle regulation, DNA repair, PI3K signaling, and RAS signaling. The assay also estimates a genome-wide copy number profile at 300 kb resolution, enabling absolute copy number quantification and detection of genome duplication events.

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700 - 1500€ per sample, depending on order volume. Sample shipping and analysis of matched germline samples is free of charge.

Panel content

GeneAnalyzed regions
AGO2Coding regions
AKT1Coding regions
AKT2Coding regions
ALKCoding regions
APCCoding regions
ATMCoding regions
ATRCoding regions
ATRXCoding regions
BRAFCoding regions
BRCA1Coding regions
BRCA2Coding regions
BCORL1Coding regions
CCND1Coding regions
CCNE1Coding regions
CDK12Coding regions
CHD4Coding regions
CREBBPCoding regions
EMSYCoding regions
EP300Coding regions
EXT1Coding regions
FAT1Coding regions
FAT3Coding regions
FAT4Coding regions
GRIN2ACoding regions
INSRCoding regions
KAT6BCoding regions
KDRCoding regions
KMT2ACoding regions
KMT2CCoding regions
KRASCoding regions
LRP1BCoding regions
LRRK2Coding regions
MECOMCoding regions
MGACoding regions
MKI67Coding regions
MTORCoding regions
MYCCoding regions
MYH9Coding regions
NCOR2Coding regions
NDRG1Coding regions
NF1Coding regions
NOTCH3Coding regions
NOTCH4Coding regions
NRASCoding regions
PALB2Coding regions
PCLOCoding regions
PDE4DIPCoding regions
PIK3CACoding regions
PPP2R2ACoding regions
PTENCoding regions
RB1Coding regions
RELNCoding regions
RNF213Coding regions
SPENCoding regions
SOX2Coding regions
TERCCoding regions
TERTCoding regions + promoter
TP53Coding regions + 5'-UTR
TP63Coding regions
TRRAPCoding regions
ZFHX3Coding regions
Whole genomeProbes tiled at 300 kb intervals for genome-wide copy number analysis


Our circulating tumor DNA analysis methodology has been validated in internationally leading studies comparing circulating tumor DNA profiles against time-matched metastatic tissue biopsies and diagnostic biopsies: