Comprehensive lung cancer assay

The Fluivia comprehensive lung cancer assay detects somatic mutations, copy number changes, rearrangements and germline variants in 67 lung cancer genes. The test can be used with circulating tumor DNA, fresh frozen cancer tissue, or FFPE cancer tissue. The assay interrogates all genes that are recurrently altered at the DNA level in lung cancer, including genes related to cell cycle regulation, growth factor receptor signaling, chromating remodeling, and oxidative stress response. Recurrent gene fusion events involving ALK, ROS1, RET, NTRK1, NTRK2 and NTRK3 are also detected by sequencing the intronic fusion breakpoint regions. The assay also estimates a genome-wide copy number profile at 300 kb resolution, enabling absolute copy number quantification and detection of genome duplication events.

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700 - 1500€ per sample, depending on order volume. Sample shipping and analysis of matched germline samples is free of charge.

Panel content

GeneAnalyzed regions
ALKCoding regions + fusion breakpoint region
ARID1ACoding regions
ATMCoding regions
BRAFCoding regions
CCND1Coding regions
CCND3Coding regions
CCNE1Coding regions
CDKN2ACoding regions
CPS1Coding regions
EGFRCoding regions
EPHA3Coding regions
EPHA5Coding regions
ERBB2Coding regions
ERBB4Coding regions
ETV6Fusion breakpoint region
FAT4Coding regions
FAT1Coding regions
FGFR1Coding regions
FGFR2Coding regions
FGFR3Coding regions
GRIN2ACoding regions
HGFCoding regions
KDRCoding regions
KEAP1Coding regions
KITCoding regions
KMT2CCoding regions
KMT2DCoding regions
KRASCoding regions
LRP1BCoding regions
LRRK2Coding regions
MDM2Coding regions
MECOMCoding regions
MEK1Coding regions
METCoding regions
MGACoding regions
MYCCoding regions
NF1Coding regions
NFE2L2Coding regions
NKX2-1Coding regions
NTRK1Fusion breakpoint region
NTRK2Fusion breakpoint region
NTRK3Fusion breakpoint region
PCLOCoding regions
PDE4DIPCoding regions
PIK3CACoding regions
PRKDCCoding regions
PREX2Coding regions
PTENCoding regions
PTPRBCoding regions
PTPRCCoding regions
PTPRDCoding regions
PTPRTCoding regions
RELNCoding regions
RETCoding regions + fusion breakpoint region
RB1Coding regions
RIT1Coding regions
ROS1Coding regions + fusion breakpoint region
SETBP1Coding regions
SETD2Coding regions
SMARCA4Coding regions
SOX2Coding regions
STK11Coding regions
TERCCoding regions
TERTCoding regions + promoter region
TP53Coding regions
TRRAPCoding regions
ZNF521Coding regions
Whole genomeProbes tiled at 300 kb intervals for genome-wide copy number analysis


Our circulating tumor DNA analysis methodology has been validated in internationally leading studies comparing circulating tumor DNA profiles against time-matched metastatic tissue biopsies and diagnostic biopsies: