Comprehensive breast cancer assay

The Fluivia comprehensive breast cancer assay detects somatic mutations, copy number changes, rearrangements and germline variants in 65 breast cancer genes. The test can be used with circulating tumor DNA, fresh frozen cancer tissue, or FFPE cancer tissue. The assay interrogates all genes that are recurrently altered at the DNA level in breast cancer, including genes related to hormonal signaling, cell cycle regulation, the MAPK pathway, DNA repair, chromatin remodeling, and PI3K signaling. The assay also estimates a genome-wide copy number profile at 300 kb resolution, enabling absolute copy number quantification and detection of genome duplication events.

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700 - 1500€ per sample, depending on order volume. Sample shipping and analysis of matched germline samples is free of charge.

Panel content

GeneAnalyzed regions
AKT1Coding regions
APCCoding regions
ARID1ACoding regions
ARID2Coding regions
ATMCoding regions
ATRCoding regions
BRAFCoding regions
BRCA1Coding regions
BRCA2Coding regions
CBFBCoding regions
CCND1Coding regions
CDH1Coding regions
CDKN2ACoding regions
CDKN2BCoding regions
CHEK2Coding regions
CREBBPCoding regions
CTCFCoding regions
CYP19A1Coding regions
EGFRCoding regions
ERBB2Coding regions
ERBB3Coding regions
ESR1Coding regions
FAT1Coding regions
FGF3Coding regions
FGF4Coding regions
FGF19Coding regions
FGFR1Coding regions
FOXA1Coding regions
GATA3Coding regions
GNASCoding regions
HRASCoding regions
KMT2ACoding regions
KMT2CCoding regions
KMT2DCoding regions
KRASCoding regions
MAP2K1Coding regions
MAP2K4Coding regions
MAP3K1Coding regions
MCL1Coding regions
MEN1Coding regions
MGACoding regions
MYCCoding regions
NCOR1Coding regions
NF1Coding regions
NOTCH1Coding regions
NOTCH2Coding regions
NOTCH4Coding regions
NSD3Coding regions
PAK1Coding regions
PALB2Coding regions
PIK3CACoding regions
PIK3R1Coding regions
PTENCoding regions
PTPRDCoding regions
RARACoding regions
RB1Coding regions
RECQL4Coding regions
RUNX1Coding regions
SF3B1Coding regions
SOS1Coding regions
SPENCoding regions
STK11Coding regions
TBX3Coding regions
TP53Coding regions
ZFHX3Coding regions
Whole genomeProbes tiled at 300 kb intervals for genome-wide copy number analysis


Our circulating tumor DNA analysis methodology has been validated in internationally leading studies comparing circulating tumor DNA profiles against time-matched metastatic tissue biopsies and diagnostic biopsies: