Comprehensive breast cancer assay

The Fluivia comprehensive breast cancer assay detects somatic mutations, copy number changes, rearrangements and germline variants in 99 breast cancer genes. The test can be used with circulating tumor DNA, fresh frozen cancer tissue, or FFPE cancer tissue. The assay interrogates all genes that are recurrently altered at the DNA level in breast cancer, including genes related to hormonal signaling, cell cycle regulation, the MAPK pathway, DNA repair, chromatin remodeling, and PI3K signaling. The assay also estimates a genome-wide copy number profile at 300 kb resolution, enabling absolute copy number quantification and detection of genome duplication events.


700 - 1500€ per sample, depending on order volume. Sample shipping and analysis of matched germline samples is free of charge.

Panel content

GeneAnalyzed regions
AKT1Coding regions
APCCoding regions
ARCoding regions
ARID1ACoding regions
ARID2Coding regions
ATMCoding regions
ATRCoding regions
BRAFCoding regions
BRCA1Coding regions
BRCA2Coding regions
CBFBCoding regions
CCDC6-RETFusion breakpoint region
CCND1Coding regions + CN grid
CCND2Coding regions
CCNE1Coding regions
CDH1Coding regions
CDK12Coding regions + CN grid
CDK4Coding regions
CDK6Coding regions
CDKN2ACoding regions + CN grid
CDKN2BCoding regions + CN grid
CHEK2Coding regions
CREBBPCoding regions
CTCFCoding regions
CYP19A1Coding regions
DDR2Coding regions
DNAH3Coding regions
EGFRCoding regions
ERBB2Exons + introns + CN grid
ERBB3Coding regions
ESR1Coding regions
FAT1Coding regions
FBXW7Coding regions
FGF19Coding regions + CN grid
FGF3Coding regions + CN grid
FGF4Coding regions + CN grid
FGFR1Coding regions + CN grid
FGFR2Coding regions
FGFR3-TACC3Fusion breakpoint region + CN grid
FOXA1Coding regions
GATA3Coding regions
GNA11Coding regions
GNASCoding regions
HNF1ACoding regions
HRASCoding regions
IDH1Coding regions
JAK2Coding regions
KITCoding regions
KMT2ACoding regions
KMT2CCoding regions
KMT2DCoding regions
KRASCoding regions
MAP2K1Coding regions
MAP2K2Coding regions
MAP2K4Coding regions
MAP3K1Coding regions
MAPK1Coding regions
MCL1Coding regions
MEN1Coding regions
METCoding regions
MGACoding regions
MLH1Coding regions
MYCCoding regions + CN grid
NCOR1Coding regions
NF1Coding regions
NOTCH1Coding regions
NOTCH2Coding regions
NOTCH4Coding regions
NSD3Coding regions
NTRK3Fusion breakpoint region
PAK1Coding regions
PALB2Coding regions
PDGFRACoding regions
PIK3CACoding regions
PIK3R1Coding regions
PTENCoding regions
PTPN11Coding regions
PTPRDCoding regions
RAF1Coding regions
RARACoding regions
RB1Coding regions
RECQL4Coding regions
RETCoding regions
RHOACoding regions
RIT1Coding regions
ROS1Coding regions
RUNX1Coding regions
SF3B1Coding regions
SMAD4Coding regions
SMDCoding regions
SOS1Coding regions
SPENCoding regions
STK11Coding regions
TBX3Coding regions
TDP2Coding regions
TERTCoding regions + promoter region
TP53Coding regions
TSC1Coding regions
ZFHX3Coding regions
Whole genomeProbes tiled at 300 kb intervals for genome-wide copy number analysis


Our circulating tumor DNA analysis methodology has been validated in internationally leading studies comparing circulating tumor DNA profiles against time-matched metastatic tissue biopsies and diagnostic biopsies: